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The principal cytochrome P450 isoenzyme included seems to be CYP2E1, with CYP1A2 and CYP3A4 as further pathways. About 85% of the oral dose appears inside the urine in 24 hours of administration, most since the glucuronide conjugate, with small quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity information and facts.In … Read More